Title | FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Mosconi L, Mistur R, Switalski R, Tsui WHon, Glodzik L, Li Y, Pirraglia E, de Santi S, Reisberg B, Wisniewski T, de Leon MJ |
Journal | Eur J Nucl Med Mol Imaging |
Volume | 36 |
Issue | 5 |
Pagination | 811-22 |
Date Published | 2009 May |
ISSN | 1619-7089 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Autopsy, Brain, Cognition Disorders, Dementia, Vascular, Female, Fluorodeoxyglucose F18, Glucose, Hippocampus, Humans, Lewy Body Disease, Male, Positron-Emission Tomography |
Abstract | PURPOSE: We report the first clinicopathological series of longitudinal FDG-PET scans in post-mortem (PM) verified cognitively normal elderly (NL) followed to the onset of Alzheimer's-type dementia (DAT), and in patients with mild DAT with progressive cognitive deterioration. METHODS: Four NL subjects and three patients with mild DAT received longitudinal clinical, neuropsychological and dynamic FDG-PET examinations with arterial input functions. NL subjects were followed for 13 +/- 5 years, received FDG-PET examinations over 7 +/- 2 years, and autopsy 6 +/- 3 years after the last FDG-PET. Two NL declined to mild cognitive impairment (MCI), and two developed probable DAT before death. DAT patients were followed for 9 +/- 3 years, received FDG-PET examinations over 3 +/- 2 years, and autopsy 7 +/- 1 years after the last FDG-PET. Two DAT patients progressed to moderate-to-severe dementia and one developed vascular dementia. RESULTS: The two NL subjects who declined to DAT received a PM diagnosis of definite AD. Their FDG-PET scans indicated a progression of deficits in the cerebral metabolic rate for glucose (CMRglc) from the hippocampus to the parietotemporal and posterior cingulate cortices. One DAT patient showed AD with diffuse Lewy body disease (LBD) at PM, and her last in vivo PET was indicative of possible LBD for the presence of occipital as well as parietotemporal hypometabolism. CONCLUSION: Progressive CMRglc reductions on FDG-PET occur years in advance of clinical DAT symptoms in patients with pathologically verified disease. The FDG-PET profiles in life were consistent with the PM diagnosis. |
DOI | 10.1007/s00259-008-1039-z |
Alternate Journal | Eur J Nucl Med Mol Imaging |
PubMed ID | 19142633 |
PubMed Central ID | PMC2774795 |
Grant List | M01 RR000096 / RR / NCRR NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States R01 AG013616-17 / AG / NIA NIH HHS / United States R01 AG012101-15 / AG / NIA NIH HHS / United States P30 AG008051-199005 / AG / NIA NIH HHS / United States AG03051 / AG / NIA NIH HHS / United States AG13616 / AG / NIA NIH HHS / United States M01RR0096 / RR / NCRR NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States R01 AG022374-05 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States M01 RR000096-47 / RR / NCRR NIH HHS / United States R01 AG022374 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States R01 AG003051 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)