Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping.

TitleEvaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping.
Publication TypeJournal Article
Year of Publication2019
AuthorsMiyata M, Kakeda S, Kudo K, Iwata S, Tanaka Y, Wang Y, Korogi Y
JournalJ Cereb Blood Flow Metab
Volume39
Issue8
Pagination1648-1658
Date Published2019 08
ISSN1559-7016
KeywordsAdult, Aged, Brain, Brain Mapping, Female, Humans, Image Interpretation, Computer-Assisted, Lupus Erythematosus, Systemic, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen
Abstract

The purposes of this study are to assess the oxygen extraction fraction (OEF) changes on MRI-based quantitative susceptibility mapping (QSM) in systemic lupus erythematosus (SLE) patients and to determine whether QSM-OEF is associated with disease activity in SLE. We enrolled 42 SLE patients and 20 healthy subjects (HS) who had no pathologies on conventional brain MRI. Disease activity was assessed using SLE Disease Activity Index (SLEDAI). For the measurement of QSM-OEF, QSM data were analysed using the Perfusion Mismatch Analyzer software program. Spearman's or Pearson's correlation coefficients were calculated, and independent predictors were identified through a multiple linear regression analysis. QSM-OEF was significantly higher in SLE than that in HS (51.3 ± 10.1 vs. 40.5 ± 3.7,  < 0.001). QSM-OEF was positively correlated with SLEDAI and the presence of neuropsychiatric symptom (NPS) scores (ρ = 0.663,  < 0.001 and ρ = 0.340,  = 0.028). At multiple linear regression analysis, SLEDAI and NPS were independently associated with QSM-OEF (standardized β = 0.426,  = 0.016 and standardized β = 6.148,  = 0.029). In the SLE patients, QSM-OEF is associated with disease activity, which might predict an increased risk of stroke in SLE.

DOI10.1177/0271678X18764829
Alternate JournalJ Cereb Blood Flow Metab
PubMed ID29547080
PubMed Central IDPMC6681530
Related Institute: 
MRI Research Institute (MRIRI)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065