Title | Etanercept does not effectively treat moderate to severe alopecia areata: an open-label study. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Strober BE, Siu K, Alexis AF, Kim G, Washenik K, Sinha A, Shupack JL |
Journal | J Am Acad Dermatol |
Volume | 52 |
Issue | 6 |
Pagination | 1082-4 |
Date Published | 2005 Jun |
ISSN | 1097-6787 |
Keywords | Adult, Alopecia Areata, Etanercept, Female, Humans, Immunoglobulin G, Male, Middle Aged, Pilot Projects, Prospective Studies, Receptors, Tumor Necrosis Factor, Severity of Illness Index, Treatment Failure, Tumor Necrosis Factor-alpha |
Abstract | In this prospective, open-label pilot study, we evaluated the safety and efficacy of etanercept, a TNF-alpha inhibitor, in the treatment of moderate to severe alopecia areata, alopecia totalis, or alopecia universalis. Seventeen otherwise healthy adults with moderate to severe alopecia areata were enrolled. The primary outcome measure was the extent of hair regrowth during and after the end of treatment as evaluated by the Severity of Alopecia Tool (the SALT score). After between 8 and 24 weeks of continuous treatment with etanercept 50 mg given subcutaneously twice weekly, significant regrowth of hair was not shown in any of the subjects treated. Based on these results, etanercept appears to be ineffective in treating subjects with treatment-refractory, moderate to severe alopecia areata, alopecia totalis, or alopecia universalis. |
DOI | 10.1016/j.jaad.2005.03.039 |
Alternate Journal | J Am Acad Dermatol |
PubMed ID | 15928633 |
Related Institute:
MRI Research Institute (MRIRI)