| Title | Elevated cerebellar glucose metabolism in microvascular white matter disease: normal aging and Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 1988 |
| Authors | Klinger A, de Leon MJ, George AE, Miller JD, Wolf AP |
| Journal | J Cereb Blood Flow Metab |
| Volume | 8 |
| Issue | 3 |
| Pagination | 433-5 |
| Date Published | 1988 Jun |
| ISSN | 0271-678X |
| Keywords | Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Analysis of Variance, Cerebellum, Cerebral Ventricles, Glucose, Humans, Middle Aged, Tomography, Emission-Computed |
| Abstract | Young normal, elderly, and clinically diagnosed Alzheimer disease subjects who had undergone positron emission tomography (PET) and computed tomography (CT) examinations were studied to determine the effect of periventricular white matter lesions on cerebellar glucose metabolic rates. PET-determined cerebellar metabolic rates were elevated in subjects with periventricular white matter lesions. These results suggest the cautious use of cortical-to-cerebellar ratios in future PET or single-photon-emission CT (SPECT) studies. |
| DOI | 10.1038/jcbfm.1988.80 |
| Alternate Journal | J Cereb Blood Flow Metab |
| PubMed ID | 3259243 |
| Grant List | MH 36969 / MH / NIMH NIH HHS / United States NS 15638 / NS / NINDS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)