Title | Effective motion-sensitizing magnetization preparation for black blood magnetic resonance imaging of the heart. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Nguyen TD, de Rochefort L, Spincemaille P, Cham MD, Weinsaft JW, Prince MR, Wang Y |
Journal | J Magn Reson Imaging |
Volume | 28 |
Issue | 5 |
Pagination | 1092-100 |
Date Published | 2008 Nov |
ISSN | 1053-1807 |
Keywords | Adult, Algorithms, Female, Heart, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motion, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, Signal Processing, Computer-Assisted |
Abstract | PURPOSE: To investigate the effectiveness of flow signal suppression of a motion-sensitizing magnetization preparation (MSPREP) sequence and to optimize a 2D MSPREP steady-state free precession (SSFP) sequence for black blood imaging of the heart. MATERIALS AND METHODS: Using a flow phantom, the effect of varying field of speed (FOS), b-value, voxel size, and flow pattern on the flow suppression was investigated. In seven healthy volunteers, black blood images of the heart were obtained at 1.5T with MSPREP-SSFP and double inversion recovery fast spin echo (DIR-FSE) techniques. Myocardium and blood signal-to-noise ratio (SNR) and myocardium-to-blood contrast-to-noise ratio (CNR) were measured. The optimal FOS that maximized the CNR for MSPREP-SSFP was determined. RESULTS: Phantom data demonstrated that the flow suppression was induced primarily by the velocity encoding effect. In humans, FOS=10-20 cm/s was found to maximize the CNR for short-axis (SA) and four-chamber (4C) views. Compared to DIR-FSE, MSPREP-SSFP provided similar blood SNR efficiency in the SA basal and mid-views and significantly lower blood SNR efficiency in the SA apical (P=0.02) and 4C (P=0.01) views, indicating similar or better blood suppression. CONCLUSION: Velocity encoding is the primary flow suppression mechanism of the MSPREP sequence and 2D MSPREP-SSFP black blood imaging of the heart is feasible in healthy subjects. |
DOI | 10.1002/jmri.21568 |
Alternate Journal | J Magn Reson Imaging |
PubMed ID | 18972350 |
PubMed Central ID | PMC2666444 |
Grant List | R01 HL064647 / HL / NHLBI NIH HHS / United States R01 HL064647-05A1 / HL / NHLBI NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)