Title | Dynamic T mapping by multi-spin-echo spatiotemporal encoding. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Bao Q, Ma L, Liberman G, Solomon E, Martinho RP, Frydman L |
Journal | Magn Reson Med |
Volume | 84 |
Issue | 2 |
Pagination | 895-907 |
Date Published | 2020 08 |
ISSN | 1522-2594 |
Keywords | Algorithms, Animals, Brain, Echo-Planar Imaging, Magnetic Resonance Imaging, Mice, Phantoms, Imaging |
Abstract | PURPOSE: To develop a pulse sequence for acquiring robust, quantitative T relaxation maps in real time. METHODS: The pulse scheme relies on fully refocused spatiotemporally encoded multi-spin-echo trains, which provide images that are significantly less distorted than spin-echo echo planar imaging-based counterparts. This enables single-shot T mapping in inhomogeneity-prone regions. Another advantage of these schemes stems from their ability to interleave multiple scans in a reference-free manner, providing an option to increase sensitivity and spatial resolution with minimal motional artifacts. RESULTS: The method was implemented in preclinical and clinical scanners, where single-shot acquisitions delivered reliable T maps in ≤200 ms with ≈250 µm and ≈3 mm resolutions, respectively. Ca. 4 times higher spatial resolutions were achieved for the motion-compensated interleaved versions of these acquisitions, delivering T maps in ca. 10 s per slice. These maps were nearly indistinguishable from multi-scan relaxometric maps requiring orders-of-magnitude longer acquisitions; this was confirmed by mice head and real-time mice abdomen 7T scans performed following contrast-agent injections, as well as by 3T human brain and breast scans. CONCLUSION: This study introduced and demonstrated a new approach for acquiring rapid and quantitative T data, which is particularly reliable when operating at high fields and/or targeting heterogeneous organs or regions. |
DOI | 10.1002/mrm.28158 |
Alternate Journal | Magn Reson Med |
PubMed ID | 31957925 |
Related Institute:
MRI Research Institute (MRIRI)