| Title | Duration of neurofibrillary changes in the hippocampal pyramidal neurons. |
| Publication Type | Journal Article |
| Year of Publication | 1998 |
| Authors | Bobinski M, Wegiel J, Tarnawski M, de Leon MJ, Reisberg B, Miller DC, Wisniewski HM |
| Journal | Brain Res |
| Volume | 799 |
| Issue | 1 |
| Pagination | 156-8 |
| Date Published | 1998 Jul 13 |
| ISSN | 0006-8993 |
| Keywords | Aged, Alzheimer Disease, Cadaver, Cell Count, Hippocampus, Humans, Middle Aged, Neurofibrillary Tangles, Pyramidal Cells, Time Factors |
| Abstract | The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyrus of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle. |
| DOI | 10.1016/s0006-8993(98)00441-7 |
| Alternate Journal | Brain Res |
| PubMed ID | 9666111 |
| Grant List | AG 03051 / AG / NIA NIH HHS / United States AG 04220 / AG / NIA NIH HHS / United States AG 08051 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)