| Title | Developing a far-red fluorogenic beta-galactosidase probe for senescent cell imaging and photoablation. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Lee SKoo, Shen Z, Han MShin, Tung C-H |
| Journal | RSC Adv |
| Volume | 12 |
| Issue | 8 |
| Pagination | 4543-4549 |
| Date Published | 2022 Feb 03 |
| ISSN | 2046-2069 |
| Abstract | A methylene blue (MB)-based beta-galactosidase (β-gal) activatable molecule, Gal-MB, was developed for senescence imaging and light-triggered senolysis. When in contact with β-gal or senescence-associated β-gal (SA-β-gal), the photoinsensitive Gal-MB becomes fluorescent. Gal-MB also offered selective phototoxicity toward β-gal expressing cells and drug-induced senescent cells, which express SA-β-gal, after light illumination at 665 nm. |
| DOI | 10.1039/d2ra00377e |
| Alternate Journal | RSC Adv |
| PubMed ID | 35425504 |
| PubMed Central ID | PMC8981090 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)