| Title | Design and synthesis of a mitochondria-targeting carrier for small molecule drugs. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Han J, Lee THoon, Tung C-H, Lee DY |
| Journal | Org Biomol Chem |
| Volume | 12 |
| Issue | 48 |
| Pagination | 9793-6 |
| Date Published | 2014 Dec 28 |
| ISSN | 1477-0539 |
| Keywords | Cell Line, Tumor, Drug Carriers, Drug Design, Drug Resistance, Neoplasm, Humans, Mitochondria, Molecular Structure, Small Molecule Libraries |
| Abstract | A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers. |
| DOI | 10.1039/c4ob01981d |
| Alternate Journal | Org Biomol Chem |
| PubMed ID | 25378226 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)