Title | Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, Hawkes CA, Koronyo-Hamaoui M, Hainsworth AH, Holtzman D, Ihara M, Jefferson A, Kalaria RN, Kipps CM, Kanninen KM, Leinonen V, McLaurin JA, Miners S, Malm T, Nicoll JAR, Piazza F, Paul G, Rich SM, Saito S, Shih A, Scholtzova H, Snyder H, Snyder P, Thormodsson FRutur, van Veluw SJ, Weller RO, Werring DJ, Wilcock D, Wilson MR, Zlokovic BV, Verma A |
Journal | Alzheimers Dement (Amst) |
Volume | 12 |
Issue | 1 |
Pagination | e12053 |
Date Published | 2020 |
ISSN | 2352-8729 |
Abstract | Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment. |
DOI | 10.1002/dad2.12053 |
Alternate Journal | Alzheimers Dement (Amst) |
PubMed ID | 32775596 |
PubMed Central ID | PMC7396859 |
Grant List | P30 AG066512 / AG / NIA NIH HHS / United States R01 AG062572 / AG / NIA NIH HHS / United States G0900652 / MRC_ / Medical Research Council / United Kingdom G0800701/1 / NC3RS_ / National Centre for the Replacement, Refinement and Reduction of Animals in Research / United Kingdom G0400074 / MRC_ / Medical Research Council / United Kingdom R01 NS104127 / NS / NINDS NIH HHS / United States MR/L023784/2 / MRC_ / Medical Research Council / United Kingdom G0502157 / MRC_ / Medical Research Council / United Kingdom 151 / ALZS_ / Alzheimer's Society / United Kingdom G1100540 / MRC_ / Medical Research Council / United Kingdom |
Related Institute:
Brain Health Imaging Institute (BHII)