Title | Cerebrospinal fluid biomarkers of Alzheimer's disease in healthy elderly. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Randall C, Mosconi L, de Leon M, Glodzik L |
Journal | Front Biosci (Landmark Ed) |
Volume | 18 |
Issue | 3 |
Pagination | 1150-73 |
Date Published | 2013 06 01 |
ISSN | 2768-6698 |
Keywords | Aged, Alzheimer Disease, Apolipoproteins E, Biomarkers, Humans, Risk Factors |
Abstract | Numerous studies have shown that Alzheimer's Disease (AD) pathology begins before the onset of clinical symptoms. Because therapies are likely to be more effective if they are implemented early in the disease progression, it is necessary to identify reliable biomarkers to detect AD pathology in the early stages of the disease, ideally in presymptomatic individuals. Recent research has identified three candidate cerebrospinal fluid (CSF) biomarkers that reflect AD pathology: amyloid beta, total tau protein (t-tau), and tau protein phosphorylated at AD-specific epitopes (p-tau). They are useful in supporting the AD diagnosis and have predictive value for AD when patients are in the stage of mild cognitive impairment (MCI). However, their predictive utility in cognitively healthy subjects is still being evaluated. We conducted a review of studies published between 1993 and 2011 and summarized their findings on the role of CSF biomarkers for AD in healthy elderly. |
DOI | 10.2741/4170 |
Alternate Journal | Front Biosci (Landmark Ed) |
PubMed ID | 23747874 |
PubMed Central ID | PMC3904672 |
Grant List | R01 AG022374 / AG / NIA NIH HHS / United States R01 HL111724 / HL / NHLBI NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States HL-111724-01 / HL / NHLBI NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)