| Title | The cerebrospinal fluid "Alzheimer profile": easily said, but what does it mean? |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Duits FH, Teunissen CE, Bouwman FH, Visser P-J, Mattsson N, Zetterberg H, Blennow K, Hansson O, Minthon L, Andreasen N, Marcusson J, Wallin A, Rikkert MOlde, Tsolaki M, Parnetti L, Herukka S-K, Hampel H, de Leon MJ, Schröder J, Aarsland D, Blankenstein MA, Scheltens P, van der Flier WM |
| Journal | Alzheimers Dement |
| Volume | 10 |
| Issue | 6 |
| Pagination | 713-723.e2 |
| Date Published | 2014 Nov |
| ISSN | 1552-5279 |
| Keywords | Aged, Alzheimer Disease, Amyloid beta-Peptides, Analysis of Variance, Apolipoproteins E, Cognition Disorders, Cohort Studies, Diagnosis, Differential, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Netherlands, Peptide Fragments, Phosphorylation, Regression Analysis, ROC Curve, tau Proteins |
| Abstract | BACKGROUND: We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-ß1-42 (Aβ42), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD). METHODS: We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). RESULTS: Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/Aβ42 ratio and 0.08 for the p-tau/Aβ42 ratio. Ratios performed similar to formulas (sensitivity, 91%-93%; specificity, 81%-84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/Aβ42 ratio. CONCLUSIONS: A tau/Aβ42 ratio of >0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers. |
| DOI | 10.1016/j.jalz.2013.12.023 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 24721526 |
| Grant List | R01 AG012101 / AG / NIA NIH HHS / United States R01 AG022374 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)