BOLD neurovascular coupling does not change significantly with normal aging.

TitleBOLD neurovascular coupling does not change significantly with normal aging.
Publication TypeJournal Article
Year of Publication2017
AuthorsGrinband J, Steffener J, Razlighi QR, Stern Y
JournalHum Brain Mapp
Volume38
Issue7
Pagination3538-3551
Date Published2017 Jul
ISSN1097-0193
Abstract

Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. Using deconvolution, we found that age does not have a significant effect on the time course of the hemodynamic impulse response function or on the slope of the BOLD versus stimulus duration relationship. These results suggest that in cognitive studies of healthy aging, group differences in BOLD activation are likely due to age-related changes in cognitive-neural interactions and information processing rather than to impairments in neurovascular coupling. Hum Brain Mapp 38:3538-3551, 2017. © 2017 Wiley Periodicals, Inc.

DOI10.1002/hbm.23608
Alternate JournalHum Brain Mapp
PubMed ID28419680
PubMed Central IDPMC5882590
Grant ListRF1 AG038465, K01-AG044467 / AG / NIA NIH HHS / United States
R01 AG038465 / AG / NIA NIH HHS / United States
R01 AG026158 / AG / NIA NIH HHS / United States
K01 AG044467 / AG / NIA NIH HHS / United States
RF1 AG038465 / AG / NIA NIH HHS / United States
Related Institute: 
Brain Health Imaging Institute (BHII)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065