Title | Body composition in premature adrenarche by structural MRI, 1H MRS and DXA. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Leibel N, Shen W, Mao X, Punyanitya M, Gallagher D, Horlick M, Shungu DC, Oberfield SE |
Journal | J Pediatr Endocrinol Metab |
Volume | 22 |
Issue | 4 |
Pagination | 301-7 |
Date Published | 2009 Apr |
ISSN | 0334-018X |
Keywords | Absorptiometry, Photon, Adrenarche, Body Composition, Child, Female, Humans, Intra-Abdominal Fat, Lipid Metabolism, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Muscle, Skeletal, Puberty, Precocious, Subcutaneous Fat |
Abstract | BACKGROUND: Premature adrenarche (PA) is recognized to be a possible precursor of polycystic ovarian syndrome, type 2 diabetes mellitus and cardiovascular disease. Visceral adiposity and increased intramyocellular lipid (IMCL) are associated with insulin resistance and increased risk of cardiovascular disease. AIM: To determine whether prepubertal girls with PA have altered visceral adiposity and/or increased muscle lipid content compared to prepubertal girls without PA using proton magnetic resonance imaging (MRI) and spectroscopy (1H MRS). PATIENTS AND METHODS: We performed total body dual energy X-ray absorptiometry (DXA) scans, MRI of the trunk, and MRS of the tibialis anterior muscle in the right calf on six girls with PA and eight prepubertal controls. RESULTS: Amount of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), and VAT to SAT ratio did not differ significantly between the PA and control girls. Those with PA, however, had significantly greater IMCL than controls (p = 0.004). CONCLUSIONS: This study adds further evidence that PA is not a benign condition, and future studies investigating early intervention with dietary and exercise counseling may help diminish potential risk for diabetes mellitus and/or cardiovascular disease. |
DOI | 10.1515/jpem.2009.22.4.301 |
Alternate Journal | J Pediatr Endocrinol Metab |
PubMed ID | 19554803 |
PubMed Central ID | PMC2873039 |
Grant List | P30 DK026687 / DK / NIDDK NIH HHS / United States P30 DK026687-289012 / DK / NIDDK NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)