| Title | Bidentate iminodiacetate modified dendrimer for bone imaging. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Pes L, Kim Y, Tung C-H |
| Journal | Bioorg Med Chem Lett |
| Volume | 27 |
| Issue | 5 |
| Pagination | 1252-1255 |
| Date Published | 2017 03 01 |
| ISSN | 1464-3405 |
| Keywords | Administration, Intravenous, Animals, Bone and Bones, Dendrimers, Diagnostic Imaging, Fluorescent Dyes, Imino Acids, Mice, Molecular Structure, Polylysine |
| Abstract | A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite, calcium oxalate and calcium phosphate salts. In mice, the probe offered vivid skeletal details after intravenous delivery. |
| DOI | 10.1016/j.bmcl.2017.01.059 |
| Alternate Journal | Bioorg Med Chem Lett |
| PubMed ID | 28153357 |
| PubMed Central ID | PMC5328641 |
| Grant List | R01 GM094880 / GM / NIGMS NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)