| Title | Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Zhang W, Zhang Z, Tung C-H |
| Journal | Chem Commun (Camb) |
| Volume | 53 |
| Issue | 4 |
| Pagination | 779-782 |
| Date Published | 2017 Jan 05 |
| ISSN | 1364-548X |
| Keywords | Antineoplastic Agents, Cell Proliferation, Cisplatin, Dose-Response Relationship, Drug, Drug Carriers, Drug Screening Assays, Antitumor, Humans, Hyaluronic Acid, Molecular Structure, Nanostructures, Structure-Activity Relationship, Tumor Cells, Cultured |
| Abstract | A cisplatin templated nanogel with targeting capability was synthesized, inspired by cisplatin as a chemotherapeutic drug. After crosslinking the natural polysaccharide hyaluronan, a ligand for CD44, cisplatin could be removed by simple dialysis in a salt solution while the withheld drug remains entrapped. |
| DOI | 10.1039/c6cc08230k |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 27999837 |
| PubMed Central ID | PMC5319414 |
| Grant List | R01 GM094880 / GM / NIGMS NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)