| Title | A benzothiazole alkyne fluorescent sensor for Cu detection in living cell. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Qi J, Han MShin, Tung C-H |
| Journal | Bioorg Med Chem Lett |
| Volume | 22 |
| Issue | 4 |
| Pagination | 1747-9 |
| Date Published | 2012 Feb 15 |
| ISSN | 1464-3405 |
| Keywords | Alkynes, Benzothiazoles, Cells, Copper, Fluorescent Dyes, HeLa Cells, Humans, Microscopy, Confocal, Molecular Structure |
| Abstract | A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (1), was developed for Cu sensing in biological system. Dye (1) offered excellent selective over a panel of ions, only Cu(I) could change the fluorescence of dye (I) by forming copper acetylide between the terminal alkyne and Cu(I). Its potential of detecting Cu in biological system was demonstrated in cell culture. |
| DOI | 10.1016/j.bmcl.2011.12.140 |
| Alternate Journal | Bioorg Med Chem Lett |
| PubMed ID | 22297113 |
| PubMed Central ID | PMC3274586 |
| Grant List | R01 CA135312 / CA / NCI NIH HHS / United States CA135312 / CA / NCI NIH HHS / United States R01 GM094880 / GM / NIGMS NIH HHS / United States R01 GM094880-02 / GM / NIGMS NIH HHS / United States GM094880 / GM / NIGMS NIH HHS / United States R01 CA135312-04 / CA / NCI NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)