Title | Assessment of bone perfusion with contrast-enhanced magnetic resonance imaging. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Lee JH, Dyke JP, Ballon D, Ciombor DMcK, Tung G, Aaron RK |
Journal | Orthop Clin North Am |
Volume | 40 |
Issue | 2 |
Pagination | 249-57 |
Date Published | 2009 Apr |
ISSN | 1558-1373 |
Keywords | Adult, Aged, Aged, 80 and over, Animals, Bone Marrow Diseases, Contrast Media, Diagnosis, Differential, Disease Models, Animal, Edema, Femur Head, Follow-Up Studies, Gadolinium DTPA, Guinea Pigs, Humans, Injections, Intravenous, Knee Joint, Magnetic Resonance Imaging, Middle Aged, Osteoarthritis, Hip, Osteoarthritis, Knee, Osteonecrosis, Syndrome, Young Adult |
Abstract | Osteoarthritis and avascular necrosis are common clinical entities with unknown origins. Recently, vascular changes were implicated in the pathogenesis of both conditions. This article discusses the use of novel noninvasive imaging techniques as a means of assessing bone perfusion and quantifying differences seen in osteoarthritis and avascular necrosis. Review of our human data suggests that the MRI contrast dye is retained for longer periods of time, suggesting decreased perfusion out of regions of osteoarthritis and avascular necrosis. Use of such a noninvasive measure of assessing bone perfusion could be useful in the diagnosis, prevention, and treatment of not only osteoarthritis and avascular necrosis but also other entities that affect the musculoskeletal system. |
DOI | 10.1016/j.ocl.2008.12.003 |
Alternate Journal | Orthop Clin North Am |
PubMed ID | 19358910 |
PubMed Central ID | PMC2760337 |
Grant List | K24 AR002128 / AR / NIAMS NIH HHS / United States K24 AR002128-05 / AR / NIAMS NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)