| Title | APOE ε4 and risk for Alzheimer's disease: do regionally distributed white matter hyperintensities play a role? |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Brickman AM, Schupf N, Manly JJ, Stern Y, Luchsinger JA, Provenzano FA, Narkhede A, Razlighi Q, Collins-Praino L, Artero S, Akbaraly TN, Ritchie K, Mayeux R, Portet F |
| Journal | Alzheimers Dement |
| Volume | 10 |
| Issue | 6 |
| Pagination | 619-29 |
| Date Published | 2014 Nov |
| ISSN | 1552-5279 |
| Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Apolipoprotein E4, Female, Genotype, Humans, Image Processing, Computer-Assisted, Linear Models, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neurologic Examination, Neuropsychological Tests, Parietal Lobe, Retrospective Studies, White Matter |
| Abstract | BACKGROUND: We previously demonstrated that parietal lobe white matter hyperintensities (WMH) increase the risk for Alzheimer's disease (AD). Here, we examined whether individuals with apolipoprotein E gene (APOE ε4) have increased parietal WMH volume. METHODS: Participants were from the Washington Heights-Inwood Columbia Aging Project (WHICAP; n = 694, 47 with dementia) in northern Manhattan and the Etude Santé Psychologique Prévalence Risques et Traitement study (ESPRIT; n = 539, 8 with dementia) in Montpellier. The association between regional WMH and APOE ε4 was examined separately in each group and then in a combined analysis. RESULTS: In WHICAP, ε4 carriers had higher WMH volume particularly in parietal and occipital lobes. In ESPRIT, ε4 carriers had elevated WMH particularly in parietal and temporal lobes. In the combined analysis, ε4 carriers had higher WMH in parietal and occipital lobes. Increased WMH volume was associated with increased frequency of dementia irrespective of APOE ε4 status; those with the ε4 were more likely to have dementia if they also had increased parietal WMH. CONCLUSIONS: APOE ε4 is associated with increased parietal lobe WMH. |
| DOI | 10.1016/j.jalz.2014.07.155 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 25304991 |
| PubMed Central ID | PMC4252241 |
| Grant List | R01 AG034189 / AG / NIA NIH HHS / United States R21 AG043337 / AG / NIA NIH HHS / United States AG007232 / AG / NIA NIH HHS / United States AG037212 / AG / NIA NIH HHS / United States K01 AG044467 / AG / NIA NIH HHS / United States R01 AG037212 / AG / NIA NIH HHS / United States AG034189 / AG / NIA NIH HHS / United States MR/K013351/1 / MRC_ / Medical Research Council / United Kingdom AG029949 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)