Title | Anteroposterior hippocampal metabolic heterogeneity: three-dimensional multivoxel proton 1H MR spectroscopic imaging--initial findings. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | King KG, Glodzik L, Liu S, Babb JS, de Leon MJ, Gonen O |
Journal | Radiology |
Volume | 249 |
Issue | 1 |
Pagination | 242-50 |
Date Published | 2008 Oct |
ISSN | 1527-1315 |
Keywords | Adult, Age Factors, Aged, Aspartic Acid, Choline, Creatine, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Prospective Studies, Protons |
Abstract | PURPOSE: To quantify proton magnetic resonance (MR) spectroscopy-detectable metabolite concentrations along anteroposterior axis of hippocampus in healthy young and elderly subjects. MATERIALS AND METHODS: Young (three women, three men; age range, 25-35 years) and elderly (four women, two men; age range, 68-72 years) groups underwent MR imaging and proton MR spectroscopic imaging at 3 T in this HIPAA-compliant prospective study and gave institutional review board-approved written consent. Volume of interest was centered on and tilted parallel to hippocampal anteroposterior plane. Absolute N-acetylaspartate (NAA), choline, and creatine levels were obtained in each voxel, with phantom replacement. RESULTS: Mean NAA, creatine, and choline concentrations in the young group were higher in posterior hippocampus (12.9 mmol/L +/- 2.0 [standard deviation], 7.8 mmol/L +/- 1.2, 2.3 mmol/L +/- 0.4, respectively) than anterior hippocampus (8.0 mmol/L +/- 1.1, 6.0 mmol/L +/- 1.4, 1.5 mmol/L +/- 0.2; P = .005, .02, and .0002, respectively). In the elderly group, mean concentrations were higher in posterior hippocampus (8.6 mmol/L +/- 0.9, 5.6 mmol/L +/- 0.6, 1.5 mmol/L +/- 0.2, respectively) than anterior hippocampus (7.2 mmol/L +/- 1.0, 2.4 mmol/L +/- 0.3, 1.0 mmol/L +/- 0.2; P = .006, .0001, .04, respectively). Mean concentrations were significantly higher in the young group (13.2 mmol/L +/- 1.0, 7.4 mmol/L +/- 0.8, 2.1 mmol/L +/- 0.3, respectively) than in the elderly group (9.0 mmol/L +/- 1.0, 5.8 mmol/L +/- 0.8, 1.8 mmol/L +/- 0.3; P = .0001, .01, .05, respectively). Posteroanterior metabolic gradients differed: NAA decreased faster in the young group (-1.0 mmol/L x cm(-1)) than the elderly group (-0.7 mmol/L x cm(-1)); creatine and choline concentrations decreased faster in the elderly group (-0.8 and -0.058 mmol/L x cm(-1), respectively) than the young group (-0.16 and -0.008 mmol/L x cm(-1), respectively). No left-right metabolic differences were found. CONCLUSION: Significant metabolic heterogeneity was observed between groups and along anteroposterior axis of healthy hippocampus in both groups. Age matching and consistent voxel placement are important for correct comparisons of both absolute metabolic levels and metabolite ratios in longitudinal intra- and intersubject cross-sectional studies. |
DOI | 10.1148/radiol.2491071500 |
Alternate Journal | Radiology |
PubMed ID | 18695208 |
PubMed Central ID | PMC2657854 |
Grant List | R01 EB001015 / EB / NIBIB NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States M01RR00096 / RR / NCRR NIH HHS / United States RR0096 / RR / NCRR NIH HHS / United States EB01015 / EB / NIBIB NIH HHS / United States R01 EB001015-13A2 / EB / NIBIB NIH HHS / United States AG03051 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States R01 NS050520 / NS / NINDS NIH HHS / United States M01 RR000096-47 / RR / NCRR NIH HHS / United States NS050520 / NS / NINDS NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG003051-18 / AG / NIA NIH HHS / United States R01 NS050520-04 / NS / NINDS NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)