| Title | Altered glucose metabolism in microvessels from patients with Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 1989 |
| Authors | Marcus DL, de Leon MJ, Goldman J, Logan J, Christman DR, Wolf AP, Fowler JS, Hunter K, Tsai J, Pearson J |
| Journal | Ann Neurol |
| Volume | 26 |
| Issue | 1 |
| Pagination | 91-4 |
| Date Published | 1989 Jul |
| ISSN | 0364-5134 |
| Keywords | Adult, Aged, Aged, 80 and over, Alzheimer Disease, Blood Vessels, Deoxy Sugars, Deoxyglucose, Energy Metabolism, Hexokinase, Humans, In Vitro Techniques, Middle Aged, Phosphorylation, Temporal Lobe |
| Abstract | Microvessels isolated from temporal cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age-matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism. |
| DOI | 10.1002/ana.410260114 |
| Alternate Journal | Ann Neurol |
| PubMed ID | 2774504 |
| Grant List | MH35976 / MH / NIMH NIH HHS / United States MH36969 / MH / NIMH NIH HHS / United States NS15638 / NS / NINDS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)