| Title | 99mTc-MIBI scintigraphy in metastatic renal cell carcinoma: clinical validation of the relationship between 99mTc-MIBI uptake and P-glycoprotein expression in tumour tissue. |
| Publication Type | Journal Article |
| Year of Publication | 1996 |
| Authors | Derebek E, Kirkali Z, Dogan AS, Degirmenci B, Yilmaz M, Igci E, Yorukoglu K, Kovanlikaya I, Durak H |
| Journal | Eur J Nucl Med |
| Volume | 23 |
| Issue | 8 |
| Pagination | 976-9 |
| Date Published | 1996 Aug |
| ISSN | 0340-6997 |
| Keywords | Aged, ATP Binding Cassette Transporter, Subfamily B, Member 1, Carcinoma, Renal Cell, Gene Expression Regulation, Neoplastic, Humans, Kidney Neoplasms, Lung Neoplasms, Male, Radionuclide Imaging, Technetium Tc 99m Sestamibi, Thallium Radioisotopes |
| Abstract | Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) and thallium-201 imaging was performed in a patient with metastatic renal cell carcinoma (RCC), which is a well-known tumour type demonstrating P1-glycoprotein (PGP) overexpression. Two scintigraphic patterns - Tl(+)/MIBI(-) in primary tumour and Tl(+)/MIBI(+) in metastatic tumour - were observed, suggesting high- and low-level PGP expression, respectively. Immunochemical study for PGP revealed strong staining of the primary tumour cells. This case clinically validates the previously suggested relationship between 99mTc-MIBI uptake and PGP expression. |
| DOI | 10.1007/BF01084374 |
| Alternate Journal | Eur J Nucl Med |
| PubMed ID | 8753689 |
Related Institute:
MRI Research Institute (MRIRI)