A dual-tuned resonator for proton-decoupled phosphorus-31 chemical shift imaging of the brain.

TitleA dual-tuned resonator for proton-decoupled phosphorus-31 chemical shift imaging of the brain.
Publication TypeJournal Article
Year of Publication1999
AuthorsZakian KL, Koutcher JA, Ballon D
JournalMagn Reson Med
Volume41
Issue4
Pagination809-15
Date Published1999 Apr
ISSN0740-3194
KeywordsBrain, Humans, Magnetic Resonance Spectroscopy, Phantoms, Imaging, Phosphorus Isotopes
Abstract

A fully quadrature dome-shaped resonator is presented that has been dual-tuned for proton and phosphorus operation at 1.5 T. The resonator is 16.5 cm in length and 23 cm in diameter. Phantom studies were performed to demonstrate the utility of the resonator for proton imaging, shimming, and proton-decoupled phosphorus spectroscopy. In human subjects, proton-decoupled phosphorus chemical shift imaging spectra of the brain were acquired at 27 cm3 resolution in 34 min. Volunteer studies demonstrated improved resolution of phosphomonoesters, phosphodiesters, and nucleoside triphosphates due to proton decoupling. Sensitive coverage of the brain extended from the most superior cerebral cortex to the cerebellum. Acquisition of good quality 31P spectra over this volume is due to the dome structure as well as quadrature operation at both proton and phosphorus frequencies.

DOI10.1002/(sici)1522-2594(199904)41:4<809::aid-mrm21>3.0.co;2-8
Alternate JournalMagn Reson Med
PubMed ID10332858
Grant List1U01CA62560-01 / CA / NCI NIH HHS / United States
Related Institute: 
MRI Research Institute (MRIRI)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065