| Title | 23Na-NMR study of ion transport across vesicle membranes facilitated by phenylalanine analogs of gramicidin. |
| Publication Type | Journal Article |
| Year of Publication | 1993 |
| Authors | Hinton JF, Easton PL, Newkirk DK, Shungu DC |
| Journal | Biochim Biophys Acta |
| Volume | 1146 |
| Issue | 2 |
| Pagination | 191-6 |
| Date Published | 1993 Mar 14 |
| ISSN | 0006-3002 |
| Keywords | Gramicidin, Ion Transport, Magnetic Resonance Spectroscopy, Membranes, Phenylalanine, Sodium, Temperature, Tryptophan |
| Abstract | The transport of Na+ ions across phosphatidylcholine/phosphatidylglycerol large unilamellar vesicle membranes facilitated by phenylalanine analogs of gramicidin A has been studied using 23Na-NMR spectroscopy. The four analogs studied were Phe9-, Phe11-, Phe13-and Phe15-gramicidin A. These analogs were found to transport Na+ ions in the following order Phe15 > Phe13 > Phe11 > Phe9. The entropy and enthalpy of activation for the transport of Na+ ions were determined for each analog. A correlation is made between the activation enthalpies and the single channel conductance values of the analogs. |
| DOI | 10.1016/0005-2736(93)90355-4 |
| Alternate Journal | Biochim Biophys Acta |
| PubMed ID | 7680900 |
Related Institute:
MRI Research Institute (MRIRI)