Title | Flip angle profile correction for T₁ and T₂ quantification with look-locker inversion recovery 2D steady-state free precession imaging. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Cooper MA, Nguyen TD, Spincemaille P, Prince MR, Weinsaft JW, Wang Y |
Journal | Magn Reson Med |
Volume | 68 |
Issue | 5 |
Pagination | 1579-85 |
Date Published | 2012 Nov |
ISSN | 1522-2594 |
Keywords | Algorithms, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Muscle, Skeletal, Reproducibility of Results, Sensitivity and Specificity |
Abstract | Fast methods using balanced steady-state free precession have been developed to reduce the scan time of T₁ and T₂ mapping. However, flip angle (FA) profiles created by the short radiofrequency pulses used in steady-state free precession deviate substantially from the ideal rectangular profile, causing T₁ and T₂ mapping errors. The purpose of this study was to develop a FA profile correction for T₁ and T₂ mapping with Look-Locker 2D inversion recovery steady-state free precession and to validate this method using 2D spin echo as a reference standard. Phantom studies showed consistent improvement in T₁ and T₂ accuracy using profile correction at multiple FAs. Over six human calves, profile correction provided muscle T₁ estimates with mean error ranging from excellent (-0.6%) at repetition time/FA = 18 ms/60° to acceptable (6.8%) at repetition time/FA = 4.9 ms/30°, while muscle T₂ estimates were less accurate with mean errors of 31.2% and 47.9%, respectively. |
DOI | 10.1002/mrm.24151 |
Alternate Journal | Magn Reson Med |
PubMed ID | 22294428 |
PubMed Central ID | PMC3342445 |
Grant List | R01 EB013443-02 / EB / NIBIB NIH HHS / United States HL064647 / HL / NHLBI NIH HHS / United States R01 HL062994-10 / HL / NHLBI NIH HHS / United States R01 HL062994 / HL / NHLBI NIH HHS / United States R01 HL064647 / HL / NHLBI NIH HHS / United States R01 HL064647-08 / HL / NHLBI NIH HHS / United States R01 EB013443 / EB / NIBIB NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)