| Title | A study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Yassin MA, Nehmeh SA, Nashwan AJ, Kohla SA, Mohamed SF, Ismail OM, Sabbagh AAl, Ibrahim F, Soliman DS, Szabados L, Fayad H |
| Journal | Medicine (Baltimore) |
| Volume | 99 |
| Issue | 45 |
| Pagination | e23088 |
| Date Published | 2020 Nov 06 |
| ISSN | 1536-5964 |
| Keywords | Clinical Trials, Phase I as Topic, Dideoxynucleosides, Humans, Positron Emission Tomography Computed Tomography, Primary Myelofibrosis, Thrombocythemia, Essential |
| Abstract | The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden.This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017. |
| DOI | 10.1097/MD.0000000000023088 |
| Alternate Journal | Medicine (Baltimore) |
| PubMed ID | 33157979 |
| PubMed Central ID | PMC7647608 |