| Title | Positron emission tomographic studies of aging and Alzheimer disease. |
| Publication Type | Journal Article |
| Year of Publication | 1983 |
| Authors | de Leon MJ, Ferris SH, George AE, Christman DR, Fowler JS, Gentes C, Reisberg B, Gee B, Emmerich M, Yonekura Y, Brodie J, Kricheff II, Wolf AP |
| Journal | AJNR Am J Neuroradiol |
| Volume | 4 |
| Issue | 3 |
| Pagination | 568-71 |
| Date Published | 1983 May-Jun |
| ISSN | 0195-6108 |
| Keywords | Adult, Aged, Aging, Alzheimer Disease, Blood Glucose, Dementia, Deoxyglucose, Fluorodeoxyglucose F18, Humans, Middle Aged, Tomography, Emission-Computed |
| Abstract | In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia. |
| Alternate Journal | AJNR Am J Neuroradiol |
| PubMed ID | 6410799 |
| PubMed Central ID | PMC8334899 |
| Grant List | MH 36969-01 / MH / NIMH NIH HHS / United States NS 15638 / NS / NINDS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)