| Title | Positron emission tomography studies of normal aging: a replication of PET III and 18-FDG using PET VI and 11-CDG. |
| Publication Type | Journal Article |
| Year of Publication | 1987 |
| Authors | de Leon MJ, George AE, Tomanelli J, Christman D, Kluger A, Miller J, Ferris SH, Fowler J, Brodie JD, van Gelder P |
| Journal | Neurobiol Aging |
| Volume | 8 |
| Issue | 4 |
| Pagination | 319-23 |
| Date Published | 1987 Jul-Aug |
| ISSN | 0197-4580 |
| Keywords | Adult, Aged, Aging, Atrophy, Brain, Cerebral Ventriculography, Deoxyglucose, Fluorodeoxyglucose F18, Glucose, Humans, Middle Aged, Tomography, Emission-Computed |
| Abstract | Using PET VI and 11-CDG we replicated our earlier PET III and 18-FDG normal aging findings. Examination of young and old normal volunteers revealed the absence of any absolute regional age-related changes in glucose utilization. For the combined sample (N = 81) we did find evidence to suggest a relative hypofrontal change with increasing age. A strong relationship between age and ventricular size (CT) was also found. These findings suggest the preserved glucose metabolism of the resting aging brain in the presence of structural atrophic changes. |
| DOI | 10.1016/0197-4580(87)90070-4 |
| Alternate Journal | Neurobiol Aging |
| PubMed ID | 3498127 |
| Grant List | MH 36969 / MH / NIMH NIH HHS / United States NS 15636 / NS / NINDS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)