Dynamic contrast-enhanced (DCE) MRI has been used to measure important tumor microenvironmental parameters, such as plasma flow (Fp), vascular permeability surface area product (PS), vascular plasma volume fraction (vp), and extravascular extracellular volume fraction (ve), that can be used for diagnosis of cancer as well as for prediction and monitoring of treatment response. However, accurate...
Early-stage ovarian cancer is typically asymptomatic. Despite successful initial treatments, 80–90% of women with advanced cancer experience tumor recurrence. For real-time ovarian cancer surgeries, we have identified an optimized pH-sensitive near-infrared fluorogenic dye (CypH-11) which remains non-fluorescent in normal tissues but becomes fluorescent immediately upon contact with cancer tissue...
The main limitations of the use of nanoparticles as drug delivery platform for cancer treatment are the inconsistent deep-tissue targeting resulting in a lack of tumor penetration, and the incomplete drug release on tumor site leading to a depreciation of safety and therapeutic efficacy. The nanofiber technology allows to carry more drugs to the metastatic lung tumors and favors the local...
Both chemotherapy and radiation therapy (RT) are frequently used in the curative-intent, adjuvant therapy, and palliative treatment of lung metastases. However, these approaches suffer from lack of specificity and high toxicity leading to treatment failure and/or resistance, disease relapse, and adverse effects. For instance, a more aggressive and multidisciplinary strategy need to be considered...
