By hitting multiple action mechanisms, combination therapy efficiently tackles cancer; however, drugs administered, simultaneously or sequentially, may not reach the targeted sites with the desired dose and ratio. The Tung lab develops various strategies to improve delivery efficiency and integrated therapeutic benefit; these strategies have been applied to multidrug combination therapy, self-catalyzing photodynamic therapy, and antioxidant nanomedicine.
Publications: A hybrid nanogel to preserve lysosome integrity for fluorescence imaging, ACS Nano: 2021, 15, 16442–16451 (PMID: 34612039); A multiresponsive nanohybrid to enhance lysosomal delivery of oxygen and photosensitizers, Chemistry: 2019, 25, 12801-12809 (PMID: 31381210).