Utilizing multi-modal neuroimaging techniques including fluorescence magnetic resonance imaging (fMRI), diffusion MRI (dMRI), and positron emission tomography (PET), the lab is applying new methods in network control theory to understand the influence of structure on the progression of functional brain activity, and how that relationship is altered by cognition, pharmacology, stimulation, psychopathology and neurology. Supporting a leading model of psychedelic action, the lab has demonstrated that the serotonergic psychedelics psilocybin and lysergic acid diethylamide (LSD) significantly reduce the energy required to transition between brain-states. The lab’s model specifically implicates the serotonin 2a receptor in this action. The lab continues to study how the brain’s energy landscape is modified in multiple sclerosis (MS), traumatic brain injury (TBI), stroke and depression, and finds that many of these pathologies are associated with increased energetic demands.