Award or Grant: National Institutes of Health (NIH)/National Institute on Aging (NIA) 3RF1AG038465
A comprehensive functional magnetic resonance imaging (fMRI) simulator not only helps evaluate and improve the present blood oxygenation-level-dependent (BOLD) extraction methods for false-positive detection, but it is also the only available tool for evaluating false-negatives. The fMRI simulator also keeps the whole BOLD extraction pipeline constant while simultaneously testing single-step changes to the process. For example, both head motion, which interacts with interleaved slice acquisition, and spatial normalization can have a catastrophic effect on fMRI results. Determining the optimal method for motion correction requires eliminating the effects of slice acquisition timing and spatial variability between subjects. This is possible only by using a comprehensive fMRI simulator, which we are developing.
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