Title | A task-invariant cognitive reserve network. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Stern Y, Gazes Y, Razlighi Q, Steffener J, Habeck C |
Journal | Neuroimage |
Volume | 178 |
Pagination | 36-45 |
Date Published | 2018 09 |
ISSN | 1095-9572 |
Keywords | Adult, Aged, Aged, 80 and over, Brain Mapping, Cerebral Cortex, Cognitive Aging, Cognitive Reserve, Executive Function, Humans, Intelligence, Magnetic Resonance Imaging, Memory, Short-Term, Middle Aged, Nerve Net, Psychomotor Performance, Vocabulary, Young Adult |
Abstract | The concept of cognitive reserve (CR) can explain individual differences in susceptibility to cognitive or functional impairment in the presence of age or disease-related brain changes. Epidemiologic evidence indicates that CR helps maintain performance in the face of pathology across multiple cognitive domains. We therefore tried to identify a single, "task-invariant" CR network that is active during the performance of many disparate tasks. In imaging data acquired from 255 individuals age 20-80 while performing 12 different cognitive tasks, we used an iterative approach to derive a multivariate network that was expressed during the performance of all tasks, and whose degree of expression correlated with IQ, a proxy for CR. When applied to held out data or forward applied to fMRI data from an entirely different activation task, network expression correlated with IQ. Expression of the CR pattern accounted for additional variance in fluid reasoning performance over and above the influence of cortical thickness, and also moderated between cortical thickness and reasoning performance, consistent with the behavior of a CR network. The identification of a task-invariant CR network supports the idea that life experiences may result in brain processing differences that might provide reserve against age- or disease-related changes across multiple tasks. |
DOI | 10.1016/j.neuroimage.2018.05.033 |
Alternate Journal | Neuroimage |
PubMed ID | 29772378 |
PubMed Central ID | PMC6409097 |
Grant List | R01 AG026158 / AG / NIA NIH HHS / United States K01 AG051777 / AG / NIA NIH HHS / United States RF1AG038465 / NH / NIH HHS / United States RF1 AG038465 / AG / NIA NIH HHS / United States R01 AG026158 / NH / NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)