| Title | Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Gabr MT, El-Gohary NS, El-Bendary ER, El-Kerdawy MM |
| Journal | Eur J Med Chem |
| Volume | 85 |
| Pagination | 576-92 |
| Date Published | 2014 Oct 06 |
| ISSN | 1768-3254 |
| Keywords | Antineoplastic Agents, Benzothiazoles, Cell Line, Tumor, Chemistry Techniques, Synthetic, Drug Screening Assays, Antitumor, ErbB Receptors, Humans, Models, Molecular, Molecular Conformation, Structure-Activity Relationship |
| Abstract | New series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives were synthesized and characterized by analytical and spectrometrical methods (IR, HRMS, (1)H and (13)C NMR). Nineteen of the synthesized compounds were selected by the National Cancer Institute (NCI), USA, to be screened for their antitumor activity at a single dose (10 μM) against a panel of 60 cancer cell lines. The most active compounds, 4, 6, 10, 14, 17 and 20 were selected for further evaluation at five dose level screening. Compounds 17 (GI50 = 0.44 μM, TGI = 1.2 μM and LC50 MG-MID = 6.6 μM) and 4 (GI50 = 0.77 μM, TGI = 2.08 μM and LC50 MG-MID = 11.74 μM) were proved to be the most active members in this study. 3D and 2D pharmacophoric maps for the structural features of both compounds were studied. |
| DOI | 10.1016/j.ejmech.2014.07.097 |
| Alternate Journal | Eur J Med Chem |
| PubMed ID | 25127150 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)