Title | Synthesis of [1-C]Butanol via a facile solid phase extraction protocol. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Waterhouse NN, Kothari PJ, Dooley M, Hu B, de Leon MJ, Babich J, Qu W |
Journal | Appl Radiat Isot |
Volume | 159 |
Pagination | 109078 |
Date Published | 2020 May |
ISSN | 1872-9800 |
Abstract | A facile synthesis method for the preparation of [1-C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1-C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements. |
DOI | 10.1016/j.apradiso.2020.109078 |
Alternate Journal | Appl Radiat Isot |
PubMed ID | 32068145 |
Related Institute:
Brain Health Imaging Institute (BHII)