Synthesis of [1-C]Butanol via a facile solid phase extraction protocol.

TitleSynthesis of [1-C]Butanol via a facile solid phase extraction protocol.
Publication TypeJournal Article
Year of Publication2020
AuthorsWaterhouse NN, Kothari PJ, Dooley M, Hu B, de Leon MJ, Babich J, Qu W
JournalAppl Radiat Isot
Volume159
Pagination109078
Date Published2020 May
ISSN1872-9800
Abstract

A facile synthesis method for the preparation of [1-C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1-C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements.

DOI10.1016/j.apradiso.2020.109078
Alternate JournalAppl Radiat Isot
PubMed ID32068145
Related Institute: 
Brain Health Imaging Institute (BHII)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065