Title | Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Apostolova LG, Mosconi L, Thompson PM, Green AE, Hwang KS, Ramirez A, Mistur R, Tsui WH, de Leon MJ |
Journal | Neurobiol Aging |
Volume | 31 |
Issue | 7 |
Pagination | 1077-88 |
Date Published | 2010 Jul |
ISSN | 1558-1497 |
Keywords | Aged, Alzheimer Disease, Atrophy, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Cognition, Cognition Disorders, Disease Progression, Female, Humans, Male, Neuropsychological Tests, Predictive Value of Tests, Prognosis, Retrospective Studies |
Abstract | Atrophic changes of the hippocampus are typically regarded as an early sign of Alzheimer's dementia (AD). Using the radial distance atrophy mapping approach, we compared the longitudinal MRI data of 10 cognitively normal elderly subjects who remained normal at 3-year and 6-year follow-up (NL-NL) and 7 cognitively normal elderly subjects who were diagnosed with mild cognitive impairment (MCI) 2.8 (range 2.0-3.9) and with AD 6.8 years (range 6.1-8.2) after baseline (NL-MCI(AD)). 3D statistical maps revealed greater hippocampal atrophy in the NL-MCI(AD) relative to the NL-NL group at baseline (left p=0.05; right p=0.06) corresponding to 10-15% CA1, and 10-25% subicular atrophy, and bilateral differences at 3-year follow-up (left p=0.001, right p<0.02) corresponding to 10-30% subicular, 10-20% CA1, and 10-20% newly developed CA2-3 atrophy. This preliminary study suggests that excess CA1 and subicular atrophy is present in cognitively normal individuals predestined to decline to amnestic MCI, while progressive involvement of the CA1 and subiculum, and atrophy spreading to the CA2-3 subfield in amnestic MCI, suggests future diagnosis of AD. |
DOI | 10.1016/j.neurobiolaging.2008.08.008 |
Alternate Journal | Neurobiol Aging |
PubMed ID | 18814937 |
PubMed Central ID | PMC2873083 |
Grant List | R01 AG022374 / AG / NIA NIH HHS / United States P50 AG016570-10 / AG / NIA NIH HHS / United States P50 AG16570 / AG / NIA NIH HHS / United States P30 AG008051-19 / AG / NIA NIH HHS / United States R01 LM005639-10 / LM / NLM NIH HHS / United States P41 RR013642-12 / RR / NCRR NIH HHS / United States R21 RR019771 / RR / NCRR NIH HHS / United States P41 RR013642-010001 / RR / NCRR NIH HHS / United States R01 LM005639 / LM / NLM NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States K23 AG026803-04 / AG / NIA NIH HHS / United States R01 MH071940-05 / MH / NIMH NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States K23 AG026803-05 / AG / NIA NIH HHS / United States R01 AG013616-17 / AG / NIA NIH HHS / United States RR019771 / RR / NCRR NIH HHS / United States P50 AG016570 / AG / NIA NIH HHS / United States K23 AG026803 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States P41 RR013642 / RR / NCRR NIH HHS / United States R01 AG012101-15 / AG / NIA NIH HHS / United States U54 RR021813 / RR / NCRR NIH HHS / United States U54 RR021813-02 / RR / NCRR NIH HHS / United States P30 AG008051-199005 / AG / NIA NIH HHS / United States LM05639 / LM / NLM NIH HHS / United States R01 AG013616-18A2 / AG / NIA NIH HHS / United States AG13616 / AG / NIA NIH HHS / United States R21 RR019771-02 / RR / NCRR NIH HHS / United States R01 MH071940 / MH / NIMH NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States P50 AG016570-100004 / AG / NIA NIH HHS / United States K23 AG026803-03 / AG / NIA NIH HHS / United States R01 AG022374-05 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)