Title | Structural brain changes in normal individuals with a maternal history of Alzheimer's. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Berti V, Mosconi L, Glodzik L, Li Y, Murray J, de Santi S, Pupi A, Tsui W, de Leon MJ |
Journal | Neurobiol Aging |
Volume | 32 |
Issue | 12 |
Pagination | 2325.e17-26 |
Date Published | 2011 Dec |
ISSN | 1558-1497 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mothers, Prospective Studies, Risk Factors |
Abstract | Having a parent affected with late-onset Alzheimer's disease (LOAD) is a major risk factor for developing the disease among cognitively normal (NL) individuals. This magnetic resonance imaging (MRI) study examines whether NL with a LOAD-affected parent show preclinical brain atrophy, and whether there are parent-of-origin effects. Voxel-based morphometry (VBM) on Statistical parametric mapping (SPM8) was used to examine volumetric T1-MRI scans of 60 late-middle-aged NL subjects, divided into 3 size-matched, demographically balanced groups of 20 subjects each, including NL with a maternal (FHm), paternal (FHp), or negative family history (FH-) of LOAD. There were no group differences for clinical and neuropsychological measures, and ApoE status. On VBM, FHm showed reduced gray matter volumes (GMV) in frontal, parietal, and temporal cortices and precuneus as compared with FH-, and in precuneus compared with FHp (p < 0.05, family-wise error [FWE]-corrected). Results remained significant controlling for age, gender, education, ApoE, and total intracranial volume. No differences were observed between FHp and FH- in any regions. NL FHm showed reduced GMV in LOAD-affected brain regions compared with FH- and FHp, indicating higher risk for Alzheimer's disease. Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals. |
DOI | 10.1016/j.neurobiolaging.2011.01.001 |
Alternate Journal | Neurobiol Aging |
PubMed ID | 21316814 |
PubMed Central ID | PMC3115436 |
Grant List | R01 AG022374 / AG / NIA NIH HHS / United States R01 AG035137 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG032554 / AG / NIA NIH HHS / United States AG13616 / AG / NIA NIH HHS / United States M01RR0096 / RR / NCRR NIH HHS / United States R01 AG013616-20 / AG / NIA NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States R21 AG032554-02 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States R01 AG035137-02 / AG / NIA NIH HHS / United States M01 RR000096 / RR / NCRR NIH HHS / United States R01 AG022374-07 / AG / NIA NIH HHS / United States AG035137 / AG / NIA NIH HHS / United States R21 AG032554 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States R01 AG012101-15S1 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)