Title | Striatal Glutathione in First-episode Psychosis Patients Measured In Vivo with Proton Magnetic Resonance Spectroscopy. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Reyes-Madrigal F, León-Ortiz P, Mao X, Mora-Durán R, Shungu DC, de la Fuente-Sandoval C |
Journal | Arch Med Res |
Volume | 50 |
Issue | 4 |
Pagination | 207-213 |
Date Published | 2019 05 |
ISSN | 1873-5487 |
Keywords | Adult, Female, Glutathione, Humans, Male, Proton Magnetic Resonance Spectroscopy, Psychotic Disorders, Young Adult |
Abstract | Deficits of brain glutathione (GSH), the most abundant and primary antioxidant in living tissue, and associated redox imbalance are postulated to be implicated in schizophrenia. This pilot clinical study compared the levels of striatal GSH, measured in vivo with proton magnetic resonance spectroscopy (H MRS) at 3T, in 10 drug-naïve, first-episode psychosis (FEP) patients with those in 9 matched healthy control subjects. The results revealed a significant GSH deficit in FEP patients (0.92 ± 0.24 × 10) compared to the healthy control group (1.10 ± 0.10 × 10) (U = 25.00, p = 0.02), as well as a positive correlation between GSH levels and the Positive Symptoms subscale of the PANSS in the FEP group (ρ = 0.96; p <0.001). These preliminary findings suggest a possible role of striatal oxidative stress in early-stage psychosis that warrants further scrutiny and confirmation in larger studies. |
DOI | 10.1016/j.arcmed.2019.08.003 |
Alternate Journal | Arch Med Res |
PubMed ID | 31499481 |
Grant List | R01 MH075895 / MH / NIMH NIH HHS / United States R01 MH110270 / MH / NIMH NIH HHS / United States S10 OD021782 / OD / NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)