Striatal Glutathione in First-episode Psychosis Patients Measured In Vivo with Proton Magnetic Resonance Spectroscopy.

TitleStriatal Glutathione in First-episode Psychosis Patients Measured In Vivo with Proton Magnetic Resonance Spectroscopy.
Publication TypeJournal Article
Year of Publication2019
AuthorsReyes-Madrigal F, León-Ortiz P, Mao X, Mora-Durán R, Shungu DC, de la Fuente-Sandoval C
JournalArch Med Res
Volume50
Issue4
Pagination207-213
Date Published2019 05
ISSN1873-5487
KeywordsAdult, Female, Glutathione, Humans, Male, Proton Magnetic Resonance Spectroscopy, Psychotic Disorders, Young Adult
Abstract

Deficits of brain glutathione (GSH), the most abundant and primary antioxidant in living tissue, and associated redox imbalance are postulated to be implicated in schizophrenia. This pilot clinical study compared the levels of striatal GSH, measured in vivo with proton magnetic resonance spectroscopy (H MRS) at 3T, in 10 drug-naïve, first-episode psychosis (FEP) patients with those in 9 matched healthy control subjects. The results revealed a significant GSH deficit in FEP patients (0.92 ± 0.24 × 10) compared to the healthy control group (1.10 ± 0.10 × 10) (U = 25.00, p = 0.02), as well as a positive correlation between GSH levels and the Positive Symptoms subscale of the PANSS in the FEP group (ρ = 0.96; p <0.001). These preliminary findings suggest a possible role of striatal oxidative stress in early-stage psychosis that warrants further scrutiny and confirmation in larger studies.

DOI10.1016/j.arcmed.2019.08.003
Alternate JournalArch Med Res
PubMed ID31499481
Grant ListR01 MH075895 / MH / NIMH NIH HHS / United States
R01 MH110270 / MH / NIMH NIH HHS / United States
S10 OD021782 / OD / NIH HHS / United States
Related Institute: 
MRI Research Institute (MRIRI)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065