| Title | Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Kim J, Tung C-H, Choi Y |
| Journal | Chem Commun (Camb) |
| Volume | 50 |
| Issue | 73 |
| Pagination | 10600-3 |
| Date Published | 2014 Sep 21 |
| ISSN | 1364-548X |
| Keywords | Animals, Cathepsin B, Cell Line, Tumor, Cell Survival, Folate Receptors, GPI-Anchored, Folic Acid, Humans, Light, Mice, Neoplasms, Photochemotherapy, Photosensitizing Agents, Porphyrins, Spectrometry, Fluorescence, Spectrophotometry, Transplantation, Heterologous |
| Abstract | A smart dual-targeted theranostic agent becomes highly fluorescent and phototoxic only when its linker is cleaved by tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells. |
| DOI | 10.1039/c4cc04166f |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 25089302 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)