Title | Semi-automatic segmentation of the placenta into fetal and maternal compartments using intravoxel incoherent motion MRI. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | You W, Andescavage N, Zun Z, Limperopoulos C |
Journal | Proc SPIE Int Soc Opt Eng |
Volume | 10137 |
Date Published | 2017 Mar |
ISSN | 0277-786X |
Abstract | Intravoxel incoherent motion (IVIM) magnetic resonance imaging is an emerging non-invasive technique that has been recently applied to quantify in vivo global placental perfusion. We propose a robust semi-automated method for segmenting the placenta into fetal and maternal compartments from IVIM data, using a multi-label image segmentation algorithm called ''. Placental IVIM data were acquired on a 1.5T scanner from 16 healthy pregnant women between 21-37 gestational weeks. The voxel-wise perfusion fraction was then estimated after non-rigid image registration. The seed regions of the fetal and maternal compartments were determined using structural T2-weighted reference images, and improved progressively through an iterative process of the GrowCut algorithm to accurately encompass fetal and maternal compartments. We demonstrated that the placental perfusion fraction decreased in both fetal (-0.010/week) and maternal compartments (-0.013/week) while their relative difference (f-f) gradually increased with advancing gestational age (+0.003/week, p=0.065). Our preliminary results show that the proposed method was effective in distinguishing placental compartments using IVIM. |
DOI | 10.1117/12.2254610 |
Alternate Journal | Proc SPIE Int Soc Opt Eng |
PubMed ID | 28947842 |
PubMed Central ID | PMC5609721 |
Grant List | KL2 TR000076 / TR / NCATS NIH HHS / United States R01 HL116585 / HL / NHLBI NIH HHS / United States U54 HD090257 / HD / NICHD NIH HHS / United States UL1 TR000075 / TR / NCATS NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)