Title | Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | de Santi S, Pirraglia E, Barr W, Babb J, Williams S, Rogers K, Glodzik L, Brys M, Mosconi L, Reisberg B, Ferris S, de Leon MJ |
Journal | Neuropsychology |
Volume | 22 |
Issue | 4 |
Pagination | 469-84 |
Date Published | 2008 Jul |
ISSN | 0894-4105 |
Keywords | Aged, Aging, Attention, Cognition Disorders, Disease Progression, Female, Humans, Language, Longitudinal Studies, Male, Memory, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Reference Values, Sensitivity and Specificity |
Abstract | The aim of the study was to compare the performance of Robust and Conventional neuropsychological norms in predicting clinical decline among healthy adults and in mild cognitive impairment (MCI). The authors developed Robust baseline cross sectional and longitudinal change norms from 113 healthy participants retaining a normal diagnosis for at least 4 years. Baseline Conventional norms were separately created for 256 similar healthy participants without follow-up. Conventional and Robust norms were tested in an independent cohort of longitudinally studied healthy (n=223), MCI (n=136), and Alzheimer's disease (AD, n=162) participants; 84 healthy participants declined to MCI or AD (NL-->DEC), and 44 MCI declined to AD (MCI-->AD). Compared to Conventional norms, baseline Robust norms correctly identified a higher proportion of NL-->DEC with impairment in delayed memory and attention-language domains. Both norms predicted decline from MCI-->AD. Change norms for delayed memory and attention-language significantly incremented baseline classification accuracies. These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions. |
DOI | 10.1037/0894-4105.22.4.469 |
Alternate Journal | Neuropsychology |
PubMed ID | 18590359 |
PubMed Central ID | PMC2661242 |
Grant List | R01 AG022374 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States R01 AG012101-15 / AG / NIA NIH HHS / United States P30 AG008051-199005 / AG / NIA NIH HHS / United States R01 AG013616-17S1 / AG / NIA NIH HHS / United States AG13616 / AG / NIA NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States R01 AG022374-05 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)