| Title | Redox-responsive cisplatin nanogels for anticancer drug delivery. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Zhang W, Tung C-H |
| Journal | Chem Commun (Camb) |
| Volume | 54 |
| Issue | 60 |
| Pagination | 8367-8370 |
| Date Published | 2018 Jul 24 |
| ISSN | 1364-548X |
| Keywords | Antineoplastic Agents, Cell Line, Tumor, Cell Survival, Cisplatin, Dose-Response Relationship, Drug, Doxorubicin, Drug Delivery Systems, Gels, Glutathione, Humans, Hyaluronic Acid, Nanoparticles, Oxidation-Reduction, Spectrometry, Fluorescence |
| Abstract | Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance. |
| DOI | 10.1039/c8cc01795f |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 29995047 |
| PubMed Central ID | PMC6057802 |
| Grant List | R01 GM094880 / GM / NIGMS NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)