| Title | The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Reisberg B, Prichep L, Mosconi L, E John R, Glodzik-Sobanska L, Boksay I, Monteiro I, Torossian C, Vedvyas A, Ashraf N, Jamil IA, de Leon MJ |
| Journal | Alzheimers Dement |
| Volume | 4 |
| Issue | 1 Suppl 1 |
| Pagination | S98-S108 |
| Date Published | 2008 Jan |
| ISSN | 1552-5279 |
| Keywords | Alzheimer Disease, Brain, Cognition Disorders, Disease Progression, Humans, Neuropsychological Tests |
| Abstract | BACKGROUND: Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons. METHODS: The past and the emerging literature on SCI and synonymously named conditions is reviewed. RESULTS: Findings include: (1) There is support from at least one longitudinal study for a long-standing concept of SCI as a pre-mild cognitive impairment (MCI) condition lasting approximately 15years. (2) There are complex relationships between SCI and depression and anxiety. (3) Differences in SCI subjects from age-matched non-SCI persons are being published in terms of cognitive tests, hippocampal gray matter density, hippocampal volumes, cerebral metabolism, and urinary cortisol levels. Psychometric and dementia test score differences between SCI and MCI subjects have long been evident. (4) Predictive electrophysiologic features of subsequent decline in SCI subjects are being published. CONCLUSIONS: Studies of therapeutic agents in SCI treatment and resultant Alzheimer's disease prevention appear to be feasible. These trials are also necessary from a public health perspective. |
| DOI | 10.1016/j.jalz.2007.11.017 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 18632010 |
| Grant List | R01 AG022374 / AG / NIA NIH HHS / United States 90AR2160 / AR / NIAMS NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States 90AM2552 / AM / NIADDK NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States P30 AG08051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States AG09127 / AG / NIA NIH HHS / United States AG03051 / AG / NIA NIH HHS / United States MH32577 / MH / NIMH NIH HHS / United States M01 RR00096 / RR / NCRR NIH HHS / United States AG11505 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States 90AZ2791 / / PHS HHS / United States AG13616 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)