| Title | Multifunctional Nanodelivery Platform for Maximizing Nucleic Acids Combination Therapy. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Lee SKoo, Law B, Tung C-H |
| Journal | Methods Mol Biol |
| Volume | 2115 |
| Pagination | 79-90 |
| Date Published | 2020 |
| ISSN | 1940-6029 |
| Keywords | Animals, Cell Line, Tumor, Drug Carriers, Drug Delivery Systems, Female, Gold, Humans, Hyaluronic Acid, Mice, Inbred BALB C, Mice, Nude, Nanoparticles, Neoplasms, Peptides, RNA, Small Interfering, RNAi Therapeutics, Static Electricity |
| Abstract | The silencing of an oncogene with a small interfering RNA (siRNA) is a promising way for cancer therapy. Its efficacy can be further enhanced by integrating with other therapeutics; however, transporting siRNA and other active ingredients to the same location at the same time is challenging. Here, we report a novel multifunctional nanodelivery platform by sequentially layering several functional ingredients, such as siRNAs, microRNAs, peptides, and targeting ligands, onto a core through charge-charge interaction. The prepared nanovectors effectively and programmably delivered multiple active components to maximize therapeutic combination with minimal off-targeting effects. |
| DOI | 10.1007/978-1-0716-0290-4_4 |
| Alternate Journal | Methods Mol Biol |
| PubMed ID | 32006395 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)