| Title | Membrane permeable esterase-activated fluorescent imaging probe. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Kim Y, Choi Y, Weissleder R, Tung C-H |
| Journal | Bioorg Med Chem Lett |
| Volume | 17 |
| Issue | 18 |
| Pagination | 5054-7 |
| Date Published | 2007 Sep 15 |
| ISSN | 0960-894X |
| Keywords | Cell Membrane Permeability, Esterases, Microscopy, Fluorescence |
| Abstract | An esterase-triggered probe 2 derived from a cyanine-based pH sensitive dye was developed for cell labeling. Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal. |
| DOI | 10.1016/j.bmcl.2007.07.026 |
| Alternate Journal | Bioorg Med Chem Lett |
| PubMed ID | 17664067 |
| PubMed Central ID | PMC1995663 |
| Grant List | R01 CA099385 / CA / NCI NIH HHS / United States R01 CA099385-04 / CA / NCI NIH HHS / United States R33 CA114149 / CA / NCI NIH HHS / United States P50 CA086355 / CA / NCI NIH HHS / United States P50-CA86355 / CA / NCI NIH HHS / United States R33 CA114149-02 / CA / NCI NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)