| Title | Inter-operator variability in compartmental kinetic analysis of F-fluoromisonidazole dynamic PET. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Nehmeh SA, Schwartz J, Grkovski M, Yeung I, Laymon CM, Muzi M, Humm JL |
| Journal | Clin Imaging |
| Volume | 49 |
| Pagination | 121-127 |
| Date Published | 2018 May - Jun |
| ISSN | 1873-4499 |
| Keywords | Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Misonidazole, Positron-Emission Tomography, Radiopharmaceuticals |
| Abstract | PURPOSE: To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET. METHODS: Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed. RESULTS: Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs. Study-II: Up to 103% variability in tumor segmentation, and weaker ICC in KRCs (ICC-V = 0.53; ICC-K = 0.91; ICC-K/k = 0.25; ICC-k3 = 0.32; ICC-K = 0.54) existed. All KRCs were repeatable among the different operators. CONCLUSIONS: Inter-operator variability in CA of dyn-FMISO was shown to be within statistical errors. |
| DOI | 10.1016/j.clinimag.2017.12.015 |
| Alternate Journal | Clin Imaging |
| PubMed ID | 29414505 |
| PubMed Central ID | PMC6059771 |
| Grant List | U01 CA190254 / CA / NCI NIH HHS / United States P30 CA047904 / CA / NCI NIH HHS / United States R50 CA211270 / CA / NCI NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States U01 CA140230 / CA / NCI NIH HHS / United States U01 CA157442 / CA / NCI NIH HHS / United States |