| Title | First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Gabr MT, Barbault F |
| Journal | Chem Commun (Camb) |
| Volume | 56 |
| Issue | 67 |
| Pagination | 9695-9698 |
| Date Published | 2020 Aug 20 |
| ISSN | 1364-548X |
| Keywords | Alzheimer Disease, Cell Line, Cell Survival, Humans, Kinetics, MicroRNAs, Molecular Conformation, Neuroprotective Agents, Protein Binding, tau Proteins |
| Abstract | We report a new approach for the development of multitargeted therapeutics for Alzheimer's disease (AD) based on dual targeting of monomeric tau and biogenesis of microRNA-146a. Compound MG-1102 displayed a superior neuroprotective activity, in comparison to mono-targeted therapeutics, which validates the likelihood of the success of this approach in AD drug development. |
| DOI | 10.1039/d0cc04249h |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 32699863 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)