Title | The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Glodzik-Sobanska L, Pirraglia E, Brys M, de Santi S, Mosconi L, Rich KE, Switalski R, Louis LSaint, Sadowski MJ, Martiniuk F, Mehta P, Pratico D, Zinkowski RP, Blennow K, de Leon MJ |
Journal | Neurobiol Aging |
Volume | 30 |
Issue | 5 |
Pagination | 672-81 |
Date Published | 2009 May |
ISSN | 1558-1497 |
Keywords | Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amyloid beta-Peptides, Apolipoprotein E4, Apolipoproteins E, Biomarkers, Dinoprost, DNA Mutational Analysis, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Oxidative Stress, Peptide Fragments, Phosphorylation, Polymorphism, Genetic, tau Proteins |
Abstract | While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (Abeta42/Abeta40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study. |
DOI | 10.1016/j.neurobiolaging.2007.08.019 |
Alternate Journal | Neurobiol Aging |
PubMed ID | 17920160 |
PubMed Central ID | PMC2774788 |
Grant List | R01 AG022374 / AG / NIA NIH HHS / United States M01 RR000096 / RR / NCRR NIH HHS / United States MO1RR0096 / RR / NCRR NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States M01 RR000096-478521 / RR / NCRR NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States R01 AG012101-15 / AG / NIA NIH HHS / United States P30 AG008051-199005 / AG / NIA NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States R01 AG022374-05 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)