| Title | Effects of inhibition of the B subunit of DNA gyrase on conjugation in Escherichia coli. |
| Publication Type | Journal Article |
| Year of Publication | 1989 |
| Authors | Hooper DC, Wolfson JS, Tung C, Souza KS, Swartz MN |
| Journal | J Bacteriol |
| Volume | 171 |
| Issue | 4 |
| Pagination | 2235-7 |
| Date Published | 1989 Apr |
| ISSN | 0021-9193 |
| Keywords | Aminocoumarins, Conjugation, Genetic, Coumarins, DNA Topoisomerases, Type II, Escherichia coli, Hot Temperature, Nalidixic Acid, Plasmids, Topoisomerase II Inhibitors |
| Abstract | Antagonism of the DNA gyrase B subunit in the donor bacterium by coumermycin or thermal inactivation inhibited transfer of plasmid R64drd-11. Coumermycin also inhibited Hfr transfer, with kinetics after drug removal suggesting that transfer resumed from the point of inhibition, in contrast to inhibition with nalidixic acid, after which transfer reinitiated from the origin of transfer. |
| DOI | 10.1128/jb.171.4.2235-2237.1989 |
| Alternate Journal | J Bacteriol |
| PubMed ID | 2539364 |
| PubMed Central ID | PMC209885 |
| Grant List | AI 23988 / AI / NIAID NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)