Development of benzothiazole 'click-on' fluorogenic dyes.

TitleDevelopment of benzothiazole 'click-on' fluorogenic dyes.
Publication TypeJournal Article
Year of Publication2011
AuthorsQi J, Tung C-H
JournalBioorg Med Chem Lett
Volume21
Issue1
Pagination320-3
Date Published2011 Jan 01
ISSN1464-3405
KeywordsAlkynes, Azides, Benzothiazoles, Click Chemistry, Copper, Fluorescent Dyes
Abstract

'Click-on' fluorogenic reaction: a non-fluorescent benzothiazole with an electron-deficient alkyne group at 2-position reacts with azide containing molecules could form fluorescent adducts.

DOI10.1016/j.bmcl.2010.11.009
Alternate JournalBioorg Med Chem Lett
PubMed ID21111622
PubMed Central IDPMC3010281
Grant ListR01 CA135312 / CA / NCI NIH HHS / United States
CA135312 / CA / NCI NIH HHS / United States
R01 GM094880 / GM / NIGMS NIH HHS / United States
R01 GM094880-01 / GM / NIGMS NIH HHS / United States
CA114149 / CA / NCI NIH HHS / United States
R21 CA114149 / CA / NCI NIH HHS / United States
R33 CA114149 / CA / NCI NIH HHS / United States
R01 CA135312-03 / CA / NCI NIH HHS / United States
Related Institute: 
Molecular Imaging Innovations Institute (MI3)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065